New Results
“Brain age” relates to early life factors but not to accelerated brain aging
D. Vidal-Piñeiro, View ORCID ProfileY. Wang, SK. Krogsrud, IK. Amlien, WFC. Baaré, D. Bartrés-Faz, L. Bertram, A.M. Brandmaier Dr, CA. Drevon, S. Düzel, KP. Ebmeier, RN Henson, C. Junque, RA Kievit, S. Kühn, E. Leonardsen, U. Lindenberger, View ORCID ProfileKS. Madsen, F. Magnussen, AM. Mowinckel, L. Nyberg, JM. Roe, B. Segura, View ORCID ProfileØ. Sørensen, View ORCID ProfileS. Suri, E. Zsoldos, the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, KB. Walhovd, AM. Fjell
doi: https://doi.org/10.1101/2021.02.08.428915
D. Vidal-Piñeiro
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDY. Wang
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDSK. Krogsrud
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDIK. Amlien
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDWFC. Baaré
2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
PhDD. Bartrés-Faz
3Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
PhDL. Bertram
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
4Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
MDA.M. Brandmaier Dr
5Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
6Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
CA. Drevon
7Department of Nutrition, Inst Basic Med Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Science Park, Oslo, Norway
MD, PhDS. Düzel
6Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
PhDKP. Ebmeier
8Department of Psychiatry, University of Oxford, Oxford, UK
MDRN Henson
9MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
PhDC. Junque
3Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
10Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
PhDRA Kievit
9MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
11Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
S. Kühn
12Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany
13Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Germany
PhDE. Leonardsen
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
MsCU. Lindenberger
5Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
6Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
PhDKS. Madsen
2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
14Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
PhDF. Magnussen
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
MsCAM. Mowinckel
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDL. Nyberg
15Umeå Centre for Functional Brain Imaging, Umeå, Sweden; Department of Integrative Medical Biology, Physiology Section and Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
PhDJM. Roe
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDB. Segura
3Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
10Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
PhDØ. Sørensen
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
PhDS. Suri
16Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, UK
DPhilE. Zsoldos
16Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, UK
DPhilKB. Walhovd
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
17Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
PhDAM. Fjell
1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
17Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
PhDAbstract
Brain age is an influential index for quantifying brain health, assumed partially to reflect the rate of brain aging. We explicitly tested this assumption in two large datasets and found no association between cross-sectional brain age and steeper brain decline. Rather, brain age in adulthood was associated with early-life influences indexed by birth weight and polygenic scores. The results call for nuanced interpretations of cross-sectional indices of the aging brain.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Posted February 08, 2021.
“Brain age” relates to early life factors but not to accelerated brain aging
D. Vidal-Piñeiro, Y. Wang, SK. Krogsrud, IK. Amlien, WFC. Baaré, D. Bartrés-Faz, L. Bertram, A.M. Brandmaier Dr, CA. Drevon, S. Düzel, KP. Ebmeier, RN Henson, C. Junque, RA Kievit, S. Kühn, E. Leonardsen, U. Lindenberger, KS. Madsen, F. Magnussen, AM. Mowinckel, L. Nyberg, JM. Roe, B. Segura, Ø. Sørensen, S. Suri, E. Zsoldos, the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, KB. Walhovd, AM. Fjell
bioRxiv 2021.02.08.428915; doi: https://doi.org/10.1101/2021.02.08.428915
“Brain age” relates to early life factors but not to accelerated brain aging
D. Vidal-Piñeiro, Y. Wang, SK. Krogsrud, IK. Amlien, WFC. Baaré, D. Bartrés-Faz, L. Bertram, A.M. Brandmaier Dr, CA. Drevon, S. Düzel, KP. Ebmeier, RN Henson, C. Junque, RA Kievit, S. Kühn, E. Leonardsen, U. Lindenberger, KS. Madsen, F. Magnussen, AM. Mowinckel, L. Nyberg, JM. Roe, B. Segura, Ø. Sørensen, S. Suri, E. Zsoldos, the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, KB. Walhovd, AM. Fjell
bioRxiv 2021.02.08.428915; doi: https://doi.org/10.1101/2021.02.08.428915
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