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Disease variants alter transcription factor levels and methylation of their binding sites
View ORCID ProfileMarc Jan Bonder, View ORCID ProfileRené Luijk, View ORCID ProfileDaria V. Zhernakova, View ORCID ProfileMatthijs Moed, View ORCID ProfilePatrick Deelen, View ORCID ProfileMartijn Vermaat, View ORCID ProfileMaarten van Iterson, View ORCID ProfileFreerk van Dijk, View ORCID ProfileMichiel van Galen, View ORCID ProfileJan Bot, View ORCID ProfileRoderick C. Slieker, View ORCID ProfileP. Mila Jhamai, View ORCID ProfileMichael Verbiest, View ORCID ProfileH. Eka D. Suchiman, View ORCID ProfileMarijn Verkerk, View ORCID ProfileRuud van der Breggen, View ORCID ProfileJeroen van Rooij, View ORCID ProfileNico Lakenberg, View ORCID ProfileWibowo Arindrarto, View ORCID ProfileSzymon M. Kielbasa, View ORCID ProfileIris Jonkers, View ORCID ProfilePeter van ’t Hof, View ORCID ProfileIrene Nooren, View ORCID ProfileMarian Beekman, View ORCID ProfileJoris Deelen, View ORCID ProfileDiana van Heemst, View ORCID ProfileAlexandra Zhernakova, View ORCID ProfileEttje F. Tigchelaar, View ORCID ProfileMorris A. Swertz, View ORCID ProfileAlbert Hofman, View ORCID ProfileAndré G. Uitterlinden, View ORCID ProfileRené Pool, View ORCID ProfileJenny van Dongen, View ORCID ProfileJouke J. Hottenga, View ORCID ProfileCoen D.A. Stehouwer, View ORCID ProfileCarla J.H. van der Kallen, View ORCID ProfileCasper G. Schalkwijk, View ORCID ProfileLeonard H. van den Berg, View ORCID ProfileErik. W van Zwet, View ORCID ProfileHailiang Mei, View ORCID ProfileYang Li, View ORCID ProfileMathieu Lemire, View ORCID ProfileThomas J. Hudson, the BIOS Consortium, View ORCID ProfileP. Eline Slagboom, View ORCID ProfileCisca Wijmenga, View ORCID ProfileJan H. Veldink, View ORCID ProfileMarleen M.J. van Greevenbroek, View ORCID ProfileCornelia M. van Duijn, View ORCID ProfileDorret I. Boomsma, View ORCID ProfileAaron Isaacs, View ORCID ProfileRick Jansen, View ORCID ProfileJoyce B.J. van Meurs, View ORCID ProfilePeter A.C. ’t Hoen, View ORCID ProfileLude Franke, View ORCID ProfileBastiaan T. Heijmans
doi: https://doi.org/10.1101/033084
Marc Jan Bonder
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
René Luijk
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Daria V. Zhernakova
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Matthijs Moed
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Patrick Deelen
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
3Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Martijn Vermaat
4Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Maarten van Iterson
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Freerk van Dijk
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
3Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Michiel van Galen
3Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Jan Bot
5SURFsara, Amsterdam, The Netherlands
Roderick C. Slieker
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
P. Mila Jhamai
6Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands
Michael Verbiest
3Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
H. Eka D. Suchiman
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Marijn Verkerk
6Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands
Ruud van der Breggen
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Jeroen van Rooij
6Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands
Nico Lakenberg
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Wibowo Arindrarto
8Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Szymon M. Kielbasa
7Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands
Iris Jonkers
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Peter van ’t Hof
7Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands
Irene Nooren
5SURFsara, Amsterdam, The Netherlands
Marian Beekman
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Joris Deelen
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Diana van Heemst
9Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
Alexandra Zhernakova
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Ettje F. Tigchelaar
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Morris A. Swertz
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
3Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Albert Hofman
10Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands
André G. Uitterlinden
6Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands
René Pool
11Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Jenny van Dongen
11Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Jouke J. Hottenga
11Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Coen D.A. Stehouwer
12Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
Carla J.H. van der Kallen
12Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
Casper G. Schalkwijk
12Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
Leonard H. van den Berg
13Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
Erik. W van Zwet
8Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Hailiang Mei
7Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands
Yang Li
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Mathieu Lemire
14Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3
Thomas J. Hudson
14Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3
15Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5S 1A1
16Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A1
P. Eline Slagboom
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Cisca Wijmenga
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Jan H. Veldink
13Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
Marleen M.J. van Greevenbroek
12Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
Cornelia M. van Duijn
17Genetic Epidemiology Unit, Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands
Dorret I. Boomsma
11Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Aaron Isaacs
17Genetic Epidemiology Unit, Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands
Rick Jansen
18Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Joyce B.J. van Meurs
6Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands
Peter A.C. ’t Hoen
4Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Lude Franke
1Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Bastiaan T. Heijmans
2Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Article usage
Posted December 01, 2015.
Disease variants alter transcription factor levels and methylation of their binding sites
Marc Jan Bonder, René Luijk, Daria V. Zhernakova, Matthijs Moed, Patrick Deelen, Martijn Vermaat, Maarten van Iterson, Freerk van Dijk, Michiel van Galen, Jan Bot, Roderick C. Slieker, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Wibowo Arindrarto, Szymon M. Kielbasa, Iris Jonkers, Peter van ’t Hof, Irene Nooren, Marian Beekman, Joris Deelen, Diana van Heemst, Alexandra Zhernakova, Ettje F. Tigchelaar, Morris A. Swertz, Albert Hofman, André G. Uitterlinden, René Pool, Jenny van Dongen, Jouke J. Hottenga, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Casper G. Schalkwijk, Leonard H. van den Berg, Erik. W van Zwet, Hailiang Mei, Yang Li, Mathieu Lemire, Thomas J. Hudson, the BIOS Consortium, P. Eline Slagboom, Cisca Wijmenga, Jan H. Veldink, Marleen M.J. van Greevenbroek, Cornelia M. van Duijn, Dorret I. Boomsma, Aaron Isaacs, Rick Jansen, Joyce B.J. van Meurs, Peter A.C. ’t Hoen, Lude Franke, Bastiaan T. Heijmans
bioRxiv 033084; doi: https://doi.org/10.1101/033084
Disease variants alter transcription factor levels and methylation of their binding sites
Marc Jan Bonder, René Luijk, Daria V. Zhernakova, Matthijs Moed, Patrick Deelen, Martijn Vermaat, Maarten van Iterson, Freerk van Dijk, Michiel van Galen, Jan Bot, Roderick C. Slieker, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Wibowo Arindrarto, Szymon M. Kielbasa, Iris Jonkers, Peter van ’t Hof, Irene Nooren, Marian Beekman, Joris Deelen, Diana van Heemst, Alexandra Zhernakova, Ettje F. Tigchelaar, Morris A. Swertz, Albert Hofman, André G. Uitterlinden, René Pool, Jenny van Dongen, Jouke J. Hottenga, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Casper G. Schalkwijk, Leonard H. van den Berg, Erik. W van Zwet, Hailiang Mei, Yang Li, Mathieu Lemire, Thomas J. Hudson, the BIOS Consortium, P. Eline Slagboom, Cisca Wijmenga, Jan H. Veldink, Marleen M.J. van Greevenbroek, Cornelia M. van Duijn, Dorret I. Boomsma, Aaron Isaacs, Rick Jansen, Joyce B.J. van Meurs, Peter A.C. ’t Hoen, Lude Franke, Bastiaan T. Heijmans
bioRxiv 033084; doi: https://doi.org/10.1101/033084
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