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Allosteric inhibition of Aurora-A kinase by a synthetic VNAR nanobody
Selena G. Burgess, Arkadiusz Oleksy, Tommaso Cavazza, Mark W. Richards, Isabelle Vernos, David Matthews, Richard Bayliss
doi: https://doi.org/10.1101/046730
Selena G. Burgess
a Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
b Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 9HN, UK
Arkadiusz Oleksy
c Centre for Therapeutics Discovery, MRC Technology, The Accelerator Building, Stevenage, Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SGI 2FX, UK
Tommaso Cavazza
d Cell and Developmental Biology program, Centre for Genomic Regulation (CRG) and UPF, Dr. Aiguader 88, 08003 Barcelona, Spain
Mark W. Richards
a Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
b Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 9HN, UK
Isabelle Vernos
d Cell and Developmental Biology program, Centre for Genomic Regulation (CRG) and UPF, Dr. Aiguader 88, 08003 Barcelona, Spain
e Institució Catalana de Recerca i Estudis Avanpats (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain
David Matthews
c Centre for Therapeutics Discovery, MRC Technology, The Accelerator Building, Stevenage, Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SGI 2FX, UK
Richard Bayliss
a Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
b Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 9HN, UK
Article usage
Posted April 02, 2016.
Allosteric inhibition of Aurora-A kinase by a synthetic VNAR nanobody
Selena G. Burgess, Arkadiusz Oleksy, Tommaso Cavazza, Mark W. Richards, Isabelle Vernos, David Matthews, Richard Bayliss
bioRxiv 046730; doi: https://doi.org/10.1101/046730
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