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Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization
View ORCID ProfileElphège P. Nora, Anton Goloborodko, View ORCID ProfileAnne-Laure Valton, View ORCID ProfileJohan Gibcus, Alec Uebsersohn, Nezar Abdennur, Job Dekker, Leonid A. Mirny, View ORCID ProfileBenoit G. Bruneau
doi: https://doi.org/10.1101/095802
Elphège P. Nora
1.Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
2.Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA
Anton Goloborodko
3.Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Anne-Laure Valton
4.Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605-0103, USA
Johan Gibcus
4.Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605-0103, USA
Alec Uebsersohn
1.Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
2.Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA
Nezar Abdennur
3.Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Job Dekker
4.Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605-0103, USA
Leonid A. Mirny
3.Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Benoit G. Bruneau
1.Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
2.Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA
5.Department of Pediatrics, University of California, San Francisco, CA 94143 USA
6.Cardiovascular Research Institute, University of California, San Francisco, CA 94158 USA
7.lead contact
Article usage
Posted December 21, 2016.
Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization
Elphège P. Nora, Anton Goloborodko, Anne-Laure Valton, Johan Gibcus, Alec Uebsersohn, Nezar Abdennur, Job Dekker, Leonid A. Mirny, Benoit G. Bruneau
bioRxiv 095802; doi: https://doi.org/10.1101/095802
Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization
Elphège P. Nora, Anton Goloborodko, Anne-Laure Valton, Johan Gibcus, Alec Uebsersohn, Nezar Abdennur, Job Dekker, Leonid A. Mirny, Benoit G. Bruneau
bioRxiv 095802; doi: https://doi.org/10.1101/095802
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