New Results
A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer’s disease
Kuan-lin Huang, Edoardo Marcora, Anna A Pimenova, Antonio F Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah Bertelsen, Benjamin P Fairfax, Jake Czajkowski, Vincent Chouraki, Benjamin Grenier-Boley, Céline Bellenguez, Yuetiva Deming, Andrew McKenzie, Towfique Raj, Alan E Renton, John Budde, Albert Smith, Annette Fitzpatrick, Joshua C Bis, Anita DeStefano, Hieab HH Adams, M Arfan Ikram, Sven van der Lee, Jorge L. Del-Aguila, Maria Victoria Fernandez, Laura Ibañez, The International Genomics of Alzheimer's Project, The Alzheimer’s Disease Neuroimaging Initiative, Rebecca Sims, Valentina Escott-Price, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A. Pericak-Vance, Jean Charles Lambert, Cornelia van Duijn, Lenore Launer, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D Schellenberg, Bin Zhang, Ingrid Borecki, John S K Kauwe, Carlos Cruchaga, Ke Hao, Alison M Goate
doi: https://doi.org/10.1101/110957
Kuan-lin Huang
1Department of Medicine, Washington University in St. Louis, Saint Louis, MO, USA
2McDonnell Genome Institute, Washington University in St. Louis, Saint Louis, MO, USA
Edoardo Marcora
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Anna A Pimenova
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Antonio F Di Narzo
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Manav Kapoor
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Sheng Chih Jin
5Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
Oscar Harari
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Sarah Bertelsen
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Benjamin P Fairfax
7Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Jake Czajkowski
8Department of Genetics, Washington University in St. Louis, Saint Louis, MO, USA
Vincent Chouraki
9Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Benjamin Grenier-Boley
10Inserm, U1167, RID-AGE—Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France
11Univ. Lille - Excellence laboratory Labex DISTALZ, F-59000 Lille, France
12Institut Pasteur de Lille, F-59000 Lille, France
Céline Bellenguez
10Inserm, U1167, RID-AGE—Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France
11Univ. Lille - Excellence laboratory Labex DISTALZ, F-59000 Lille, France
12Institut Pasteur de Lille, F-59000 Lille, France
Yuetiva Deming
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Andrew McKenzie
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Towfique Raj
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Alan E Renton
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
John Budde
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Albert Smith
13University of Iceland, Reykjavik, Iceland
Annette Fitzpatrick
14Department of Epidemiology, University of Washington, Seattle, Washington, USA
Joshua C Bis
15Department of Medicine, University of Washington, Seattle, Washington, USA
Anita DeStefano
16Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Hieab HH Adams
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
M Arfan Ikram
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Sven van der Lee
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Jorge L. Del-Aguila
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Maria Victoria Fernandez
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Laura Ibañez
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Rebecca Sims
18Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
Valentina Escott-Price
18Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
Richard Mayeux
19Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
20Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
21Department of Neurology, Columbia University, New York, NY, USA
Jonathan L Haines
22Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
Lindsay A Farrer
12Institut Pasteur de Lille, F-59000 Lille, France
16Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
23Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA
24Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA
25Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Margaret A. Pericak-Vance
25The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
26Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA
Jean Charles Lambert
10Inserm, U1167, RID-AGE—Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France
11Univ. Lille - Excellence laboratory Labex DISTALZ, F-59000 Lille, France
12Institut Pasteur de Lille, F-59000 Lille, France
Cornelia van Duijn
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Lenore Launer
27Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA
Sudha Seshadri
9Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Julie Williams
18Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
Philippe Amouyel
10Inserm, U1167, RID-AGE—Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France
11Univ. Lille - Excellence laboratory Labex DISTALZ, F-59000 Lille, France
12Institut Pasteur de Lille, F-59000 Lille, France
28Centre Hospitalier Universitaire de Lille, U1167, F-59000 Lille, France
Gerard D Schellenberg
29Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Bin Zhang
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Ingrid Borecki
30Regeneron Pharmaceuticals, Inc, NY, USA
John S K Kauwe
31Department of Biology, Brigham Young University, Provo, Utah, USA
Carlos Cruchaga
6Department of Psychiatry, Washington University in St. Louis, Saint Louis, MO, USA
Ke Hao
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Alison M Goate
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4Ronald M. Loeb Center for Alzheimer’s disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Article usage
Posted February 26, 2017.
A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer’s disease
Kuan-lin Huang, Edoardo Marcora, Anna A Pimenova, Antonio F Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah Bertelsen, Benjamin P Fairfax, Jake Czajkowski, Vincent Chouraki, Benjamin Grenier-Boley, Céline Bellenguez, Yuetiva Deming, Andrew McKenzie, Towfique Raj, Alan E Renton, John Budde, Albert Smith, Annette Fitzpatrick, Joshua C Bis, Anita DeStefano, Hieab HH Adams, M Arfan Ikram, Sven van der Lee, Jorge L. Del-Aguila, Maria Victoria Fernandez, Laura Ibañez, The International Genomics of Alzheimer's Project, The Alzheimer’s Disease Neuroimaging Initiative, Rebecca Sims, Valentina Escott-Price, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A. Pericak-Vance, Jean Charles Lambert, Cornelia van Duijn, Lenore Launer, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D Schellenberg, Bin Zhang, Ingrid Borecki, John S K Kauwe, Carlos Cruchaga, Ke Hao, Alison M Goate
bioRxiv 110957; doi: https://doi.org/10.1101/110957
A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer’s disease
Kuan-lin Huang, Edoardo Marcora, Anna A Pimenova, Antonio F Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah Bertelsen, Benjamin P Fairfax, Jake Czajkowski, Vincent Chouraki, Benjamin Grenier-Boley, Céline Bellenguez, Yuetiva Deming, Andrew McKenzie, Towfique Raj, Alan E Renton, John Budde, Albert Smith, Annette Fitzpatrick, Joshua C Bis, Anita DeStefano, Hieab HH Adams, M Arfan Ikram, Sven van der Lee, Jorge L. Del-Aguila, Maria Victoria Fernandez, Laura Ibañez, The International Genomics of Alzheimer's Project, The Alzheimer’s Disease Neuroimaging Initiative, Rebecca Sims, Valentina Escott-Price, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A. Pericak-Vance, Jean Charles Lambert, Cornelia van Duijn, Lenore Launer, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D Schellenberg, Bin Zhang, Ingrid Borecki, John S K Kauwe, Carlos Cruchaga, Ke Hao, Alison M Goate
bioRxiv 110957; doi: https://doi.org/10.1101/110957
Subject Area
Subject Areas
- Biochemistry (11573)
- Bioengineering (8623)
- Bioinformatics (28875)
- Biophysics (14805)
- Cancer Biology (11944)
- Cell Biology (17170)
- Clinical Trials (138)
- Developmental Biology (9307)
- Ecology (14022)
- Epidemiology (2067)
- Evolutionary Biology (18129)
- Genetics (12148)
- Genomics (16619)
- Immunology (11712)
- Microbiology (27702)
- Molecular Biology (11401)
- Neuroscience (60106)
- Paleontology (448)
- Pathology (1849)
- Pharmacology and Toxicology (3184)
- Physiology (4878)
- Plant Biology (10279)
- Synthetic Biology (2849)
- Systems Biology (7291)
- Zoology (1619)