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Sinusoidal voltage protocols for rapid characterization of ion channel kinetics
View ORCID ProfileKylie A. Beattie, View ORCID ProfileAdam P. Hill, View ORCID ProfileRémi Bardenet, View ORCID ProfileYi Cui, View ORCID ProfileJamie I. Vandenberg, View ORCID ProfileDavid J. Gavaghan, View ORCID ProfileTeun P. de Boer, View ORCID ProfileGary R. Mirams
doi: https://doi.org/10.1101/100677
Kylie A. Beattie
1Computational Biology, Department of Computer Science, University of Oxford, OX1 3QD, UK
2Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA
Adam P. Hill
3Department of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
4St Vincent’s Clinical School, UNSW Sydney, Darlinghurst, NSW 2010, Australia
Rémi Bardenet
5CNRS & CRIStAL, Université de Lille, 59651 Villeneuve d’Ascq, France
Yi Cui
6Safety Evaluation and Risk Management, Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, UB11 1BS, UK
Jamie I. Vandenberg
3Department of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
4St Vincent’s Clinical School, UNSW Sydney, Darlinghurst, NSW 2010, Australia
David J. Gavaghan
1Computational Biology, Department of Computer Science, University of Oxford, OX1 3QD, UK
Teun P. de Boer
7Division of Heart & Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
Gary R. Mirams
1Computational Biology, Department of Computer Science, University of Oxford, OX1 3QD, UK
8Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, NG7 2RD, UK
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Posted March 13, 2017.
Sinusoidal voltage protocols for rapid characterization of ion channel kinetics
Kylie A. Beattie, Adam P. Hill, Rémi Bardenet, Yi Cui, Jamie I. Vandenberg, David J. Gavaghan, Teun P. de Boer, Gary R. Mirams
bioRxiv 100677; doi: https://doi.org/10.1101/100677
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