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Heterogeneity of cognitive decline in dementia: a failed attempt to take into account variable time-zero severity
View ORCID ProfileSteven J Kiddle, Alice Parodi, Caroline Johnston, Chris Wallace, View ORCID ProfileRichard JB Dobson, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), for the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL), and for the Coalition Against Major Diseases (CAMD)
doi: https://doi.org/10.1101/060830
Steven J Kiddle
1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK, SE5 8AF.
2MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK.
Alice Parodi
3MOX, Department of Mathematics, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
Caroline Johnston
1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK, SE5 8AF.
4NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK, SE5 8AF
Chris Wallace
2MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK.
5Department of Medicine, Box 157, Level 4, Cambridge Biomedical Campus, University of Cambridge, UK, CB2 0QQ.
6JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC Bldg, Addenbrooke’s Hospital, Hills Rd., Cambridge CB2 0XY UK
Richard JB Dobson
1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK, SE5 8AF.
4NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK, SE5 8AF
7Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London WC1E 6BT, UK.
aData used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at:
bData used in the preparation of this article was obtained from the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL) funded by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) which was made available at the ADNI database ( ADNI). The AIBL researchers contributed data but did not participate in analysis or writing of this report. AIBL researchers are listed at
cData used in the preparation of this article were obtained from the Coalition Against Major Diseases database (CAMD). As such, the investigators within CAMD contributed to the design and implementation of the CAMD database and/or provided data, but did not participate in the analysis of the data or the writing of this report.
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Posted July 11, 2017.
Heterogeneity of cognitive decline in dementia: a failed attempt to take into account variable time-zero severity
Steven J Kiddle, Alice Parodi, Caroline Johnston, Chris Wallace, Richard JB Dobson, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), for the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL), and for the Coalition Against Major Diseases (CAMD)
bioRxiv 060830; doi: https://doi.org/10.1101/060830
Heterogeneity of cognitive decline in dementia: a failed attempt to take into account variable time-zero severity
Steven J Kiddle, Alice Parodi, Caroline Johnston, Chris Wallace, Richard JB Dobson, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), for the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL), and for the Coalition Against Major Diseases (CAMD)
bioRxiv 060830; doi: https://doi.org/10.1101/060830
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