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Causal analyses, statistical efficiency and phenotypic precision through Recall-by-Genotype study design
Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Steve O’Rahilly, Michael J. Owen, Colin N.A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
doi: https://doi.org/10.1101/124586
Laura J. Corbin
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Vanessa Y. Tan
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
David A. Hughes
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Kaitlin H. Wade
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Dirk S. Paul
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Katherine E. Tansey
3Core Bioinformatics and Statistics Team, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF10 3XQ, UK
Frances Butcher
4Oxford School of Public Health, University of Oxford, Oxford, OX3 7LF, UK
Frank Dudbridge
5Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Joanna M. Howson
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Momodou W. Jallow
6Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
7MRC Unit The Gambia (MRCG), Atlantic Road Fajara, P.O. Box 273 Banjul the Gambia
Catherine John
5Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Nathalie Kingston
8National Institute for Health Research (NIHR) Bioresource & Cambridge Bioresource, University of Cambridge, Cambridge, CB1 8RN, UK
Cecilia M. Lindgren
9Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
10Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
11Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
12NIHR Oxford Biomedical Research Centre, OUH Hospital, Oxford, UK
Michael O’Donavan
13MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ
Steve O’Rahilly
14Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Michael J. Owen
13MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ
Colin N.A. Palmer
15Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Ewan R. Pearson
15Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Robert A. Scott
16MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK
17Statistical Genetics, Projects, Clinical Platforms, and Sciences (PCPS), GlaxoSmithKline, Research Triangle Park, NC 27709, USA
David A. van Heel
18Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
John Whittaker
6Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
19Quantitative Sciences, GlaxoSmithKline, Stevenage, UK
Tim Frayling
20Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, EX1 2LU, UK.
Martin D. Tobin
5Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
21Leicester NIHR Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Louise V. Wain
5Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
21Leicester NIHR Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
David M. Evans
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
22The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4072, Australia
Fredrik Karpe
23Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.
24NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE, UK.
Mark I. McCarthy
10Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
23Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.
24NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE, UK.
John Danesh
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
25Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
26NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
27British Heart Foundation (BHF) Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
Paul W. Franks
23Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.
28Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Sweden.
29Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden
30Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Nicholas J. Timpson
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Article usage
Posted July 31, 2017.
Causal analyses, statistical efficiency and phenotypic precision through Recall-by-Genotype study design
Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Steve O’Rahilly, Michael J. Owen, Colin N.A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
bioRxiv 124586; doi: https://doi.org/10.1101/124586
Causal analyses, statistical efficiency and phenotypic precision through Recall-by-Genotype study design
Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Steve O’Rahilly, Michael J. Owen, Colin N.A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
bioRxiv 124586; doi: https://doi.org/10.1101/124586
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