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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways
View ORCID ProfileDavid M. Howard, View ORCID ProfileMark J. Adams, View ORCID ProfileMasoud Shirali, View ORCID ProfileToni-Kim Clarke, Riccardo E. Marioni, Gail Davies, View ORCID ProfileJonathan R. I. Coleman, Clara Alloza, View ORCID ProfileXueyi Shen, Miruna C. Barbu, View ORCID ProfileEleanor M. Wigmore, View ORCID ProfileJude Gibson, View ORCID ProfileSaskia P. Hagenaars, View ORCID ProfileCathryn M. Lewis, View ORCID ProfileDaniel J. Smith, Patrick F. Sullivan, View ORCID ProfileChris S. Haley, View ORCID ProfileGerome Breen, View ORCID ProfileIan J. Deary, View ORCID ProfileAndrew M. McIntosh
doi: https://doi.org/10.1101/168732
David M. Howard
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Mark J. Adams
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Masoud Shirali
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Toni-Kim Clarke
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Riccardo E. Marioni
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Gail Davies
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
3Department of Psychology, University of Edinburgh, Edinburgh, UK
Jonathan R. I. Coleman
4MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
5NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Clara Alloza
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Xueyi Shen
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Miruna C. Barbu
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Eleanor M. Wigmore
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Jude Gibson
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Saskia P. Hagenaars
4MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
5NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Cathryn M. Lewis
4MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
5NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Daniel J. Smith
6Institute of Health and Wellbeing, University of Glasgow, UK
Patrick F. Sullivan
7Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
8Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
9Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
Chris S. Haley
10Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Gerome Breen
4MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
5NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Ian J. Deary
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
3Department of Psychology, University of Edinburgh, Edinburgh, UK
Andrew M. McIntosh
1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
3Department of Psychology, University of Edinburgh, Edinburgh, UK
Article usage
Posted August 01, 2017.
Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways
David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, Saskia P. Hagenaars, Cathryn M. Lewis, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh
bioRxiv 168732; doi: https://doi.org/10.1101/168732
Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways
David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, Saskia P. Hagenaars, Cathryn M. Lewis, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh
bioRxiv 168732; doi: https://doi.org/10.1101/168732
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