RT Journal Article SR Electronic T1 Sex-biased gene expression in Drosophila melanogaster is constrained by ontogeny and genetic architecture JF bioRxiv FD Cold Spring Harbor Laboratory SP 034728 DO 10.1101/034728 A1 FC Ingleby A1 CL Webster A1 TM Pennell A1 I Flis A1 EH Morrow YR 2016 UL http://biorxiv.org/content/early/2016/01/28/034728.abstract AB Sexual dimorphism is predicted to be constrained by the underlying genetic architecture shared between the sexes and through ontogeny, but whole-transcriptome data for both sexes across genotypes and developmental stages are lacking. Within a quantitative genetic framework, we sequenced RNA from Drosophila melanogaster at different developmental stages to examine sex-biased gene expression and how selection acts upon it. We found evidence that gene expression is constrained by both univariate and multivariate shared genetic variation between genes, sexes and developmental stages, but may be resolved by differential splicing. These results provide a comprehensive picture of how conflict over sexual dimorphism varies through development and clarifies the conditions under which it is predicted to evolve.