PT  - JOURNAL ARTICLE
AU  - Siddharth Krishna Kumar
AU  - Marcus W. Feldman
AU  - David H. Rehkopf
AU  - Shripad Tuljapurkar
TI  - Response to “Commentary on ‘Limitations of GCTA as a solution to the missing heritability problem”
AID  - 10.1101/039594
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 039594
4099  - http://biorxiv.org/content/early/2016/02/17/039594.short
4100  - http://biorxiv.org/content/early/2016/02/17/039594.full
AB  - In a recent manuscript [18], Yang and colleagues criticized our paper, ‘Limitations of GCTA as a solution to the missing heritability problem’ [9]. Henceforth we refer to our original paper as SK and the critique as YC.Here we show that their main claims are statistically invalid. We begin with an overview and the mathematical details follow in subsequent sections.