RT Journal Article
SR Electronic
T1 Declaring a tuberculosis outbreak over with genomic epidemiology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 040527
DO 10.1101/040527
A1 Hollie-Ann Hatherell
A1 Xavier Didelot
A1 Sue L. Pollock
A1 Patrick Tang
A1 Anamaria Crisan
A1 James C. Johnston
A1 Caroline Colijn
A1 Jennifer Gardy
YR 2016
UL http://biorxiv.org/content/early/2016/02/22/040527.abstract
AB We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.