PT  - JOURNAL ARTICLE
AU  - Sharon Bewick
AU  - William F. Fagan
AU  - Justin Calabrese
AU  - Folashade Agusto
TI  - Zika Virus: Endemic Versus Epidemic Dynamics and Implications for Disease Spread in the Americas
AID  - 10.1101/041897
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 041897
4099  - http://biorxiv.org/content/early/2016/02/29/041897.short
4100  - http://biorxiv.org/content/early/2016/02/29/041897.full
AB  - Since being introduced into Brazil in 2014, Zika virus (ZIKV) has spread explosively across Central and South America. Although the symptoms of ZIKV are generally mild, recent evidence suggests a relationship between prenatal exposure to ZIKV and microcephaly. This has led to widespread panic, including travel alerts and warnings to avoid pregnancy. Because ZIKV is an emerging disease, response efforts are complicated by limited understanding of disease dynamics. To this end, we develop a novel state- and class-structured compartment model for ZIKV. Our model shows that the risk of prenatal ZIKV exposure should decrease dramatically following the initial wave of disease, reaching almost undetectable levels in endemic systems. Our model also suggests that efforts to reduce ZIKV prenatal exposures through mosquito management and avoidance may have minimal benefit, and may even result in increased risk of microcephaly in later years of an outbreak.