%0 Journal Article %A Mei Hou %A Xing Tang %A Feng Tian %A Fangyuan Shi %A Fenglin Liu %A Ge Gao %T AnnoLnc: a web server for systematically annotating novel human lncRNAs %D 2016 %R 10.1101/042655 %J bioRxiv %P 042655 %X Although the repertoire of human lncRNAs has rapidly expanded, their biological function and regulation remain largely elusive. Here, we present AnnoLnc (http://annolnc.cbi.pku.edu.cn), an online portal for systematically annotating newly identified human lncRNAs. AnnoLnc offers a full spectrum of annotations covering genomic location, RNA secondary structure, expression, transcriptional regulation, miRNA interaction, protein interaction, genetic association and evolution, as well as an abstraction-based text summary and various intuitive figures to help biologists quickly grasp the essentials. In addition to an intuitive and mobile-friendly Web interactive design, AnnoLnc supports batch analysis and provides JSON-based Web Service APIs for programmatic analysis. To the best of our knowledge, AnnoLnc is the first web server to provide on-the-fly and systematic annotation for newly identified human lncRNAs. Some case studies have shown the power of AnnoLnc to inspire novel hypotheses. %U https://www.biorxiv.org/content/biorxiv/early/2016/03/07/042655.full.pdf