TY - JOUR T1 - LoLoPicker: Detecting Low-Fraction Variants in Low-Quality Cancer Samples from Whole-exome Sequencing Data JF - bioRxiv DO - 10.1101/043612 SP - 043612 AU - Jian Carrot-Zhang AU - Jacek Majewski Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/03/15/043612.abstract N2 - Summary: We developed an efficient tool dedicated to call somatic variants from whole-exome sequencing (WES) data using tumor and its matched normal tissue, plus a user-defined control panel of non-cancer samples. We showed superior performance of LoLoPicker with significantly improved specificity, especially for low-quality cancer samples such as formalin-fixed and paraffin-embedded (FFPE) samples.Implementation and Availability: The main scripts are implemented in Python 2.7.8 and the package is released at https://github.com/jcarrotzhang/LoLoPicker. ER -