%0 Journal Article %A Jian Carrot-Zhang %A Jacek Majewski %T LoLoPicker: Detecting Low-Fraction Variants in Low-Quality Cancer Samples from Whole-exome Sequencing Data %D 2016 %R 10.1101/043612 %J bioRxiv %P 043612 %X Summary: We developed an efficient tool dedicated to call somatic variants from whole-exome sequencing (WES) data using tumor and its matched normal tissue, plus a user-defined control panel of non-cancer samples. We showed superior performance of LoLoPicker with significantly improved specificity, especially for low-quality cancer samples such as formalin-fixed and paraffin-embedded (FFPE) samples.Implementation and Availability: The main scripts are implemented in Python 2.7.8 and the package is released at https://github.com/jcarrotzhang/LoLoPicker. %U https://www.biorxiv.org/content/biorxiv/early/2016/03/15/043612.full.pdf