%0 Journal Article %A Donatien Chedom-Fotso %A Ahmed Ashour Ahmed %A Christopher Yau %T OncoPhase: Quantification of somatic mutation cellular prevalence using phase information %D 2016 %R 10.1101/046631 %J bioRxiv %P 046631 %X The impact of evolutionary processes in cancer and its implications for drug response, biomarker validation and clinical outcome requires careful consideration of the evolving mutational landscape of the cancer. Genome sequencing allows us to identify mutations but the prevalence of those mutations in heterogeneous tumours must be inferred. We describe a method that we call OncoPhase to compute the prevalence of somatic point mutations from genome sequencing analysis of heterogeneous tumours that combines information from nearby phased germline variants. We show using simulations that the use of phased germline information can give improved prevalence estimates over the use of somatic variants only. %U https://www.biorxiv.org/content/biorxiv/early/2016/03/31/046631.full.pdf