RT Journal Article SR Electronic T1 Physiological and biochemical changes associated with experimental dehydration in the desert adapted cactus mouse, Peromyscus eremicus JF bioRxiv FD Cold Spring Harbor Laboratory SP 047704 DO 10.1101/047704 A1 Lauren Kordonowy A1 Kaelina Lombardo A1 Hannah Green A1 Evice Bolton A1 Sarah LaCourse A1 Matthew MacManes YR 2016 UL http://biorxiv.org/content/early/2016/04/07/047704.abstract AB Characterizing traits critical for adaptation to a given environment is an important first step in understanding how phenotypes evolve. How animals adapt to the extreme heat and aridity commonplace to deserts represents is an exceptionally interesting example of these processes, and has been the focus of study for decades. In contrast to those studies, where experiments are conducted on either wild animals or captive animals held in non-desert conditions, the study described here leverages a unique environmental chamber that replicates desert conditions for captive Peromyscus eremicus (cactus mouse). Here we establish baseline values for daily water intake and for serum electrolytes, as well as the response of these variables to experimental dehydration. In brief, P. eremicus’ daily water intake is very low. It's serum electrolytes are distinct from many previously studied animals, and its response to dehydration if profound, though not suggestive of renal impairment in the face of profound dehydration, which is atypical of mammals.