TY - JOUR T1 - Membrane insertion of‐ and membrane potential sensing by semiconductor voltage nanosensors: feasibility demonstration JF - bioRxiv DO - 10.1101/044057 SP - 044057 AU - Kyoungwon Park AU - Yung Kuo AU - Volodymyr Shvadchak AU - Antonino Ingargiola AU - Xinghong Dai AU - Lawrence Hsiung AU - Wookyeom Kim AU - Z. Hong Zhou AU - Peng Zou AU - Alex J. Levine AU - Jack Li AU - Shimon Weiss Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/16/044057.abstract N2 - We develop membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. These voltage nanosensors are designed to self-insert into the cell membrane and optically record the membrane potential via the quantum confined Stark effect, with single-particle sensitivity. We present here the approach, design rules, and feasibility proves for this concept. With further improvements, semiconductor nanoparticles could potentially be used to study signals from many neurons in a large field-of-view over a long duration. Moreover, they could potentially report and resolve voltage signals on the nanoscale. ER -