RT Journal Article SR Electronic T1 How life history can sway the fixation probability of mutants JF bioRxiv FD Cold Spring Harbor Laboratory SP 050914 DO 10.1101/050914 A1 Xiang-Yi Li A1 Shun Kurokawa A1 Stefano Giaimo A1 Arne Traulsen YR 2016 UL http://biorxiv.org/content/early/2016/04/28/050914.abstract AB In this work, we study the effects of demographic structure on evolutionary dynamics, when selection acts on reproduction, survival, or both. In contrast with the previously discovered pattern that the fixation probability of a neutral mutant decreases while population becomes younger, we show that a mutant with constant selective advantage may have a maximum or a minimum of the fixation probability in populations with an intermediate fraction of young individuals. This highlights the importance of life history and demographic structure in studying evolutionary dynamics. We also illustrate the fundamental differences between selection on reproduction and on survival when age structure is present. In addition, we evaluate the relative importance of size and structure of the population in determining the fixation probability of the mutant. Our work lays the foundation for studying also density and frequency dependent effects in populations when demographic structures cannot be neglected.