RT Journal Article
SR Electronic
T1 A Zika virus-associated microcephaly case with background exposure to STORCH agents
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 052340
DO 10.1101/052340
A1 Mauro Mitsuru Hanaoka
A1 Alexandre Fligelman Kanas
A1 Carla Torres Braconi
A1 Érica Araújo Mendes
A1 Robert Andreata Santos
A1 Luís Carlos de Souza Ferreira
A1 Marielton dos Passos Cunha
A1 Patrícia Beltrão Braga
A1 João Leonardo Mendonça Dias
A1 Carolina Manganeli Polonio
A1 David Anibal Garrido Andrade
A1 Carla Longo de Freitas
A1 Cristiano Rossato
A1 Wesley Nogueira Brandão
A1 Jean Pierre Schatzmann Peron
A1 Antonio Gomes de Amorim Filho
A1 Joelma Queiroz Andrade
A1 Rossana Pulcineli Vieira Francisco
A1 Fernando Kok
A1 Lisa Suzuki
A1 Claudia da Costa Leite
A1 Leandro Tavares Lucato
A1 Amadou Alpha Sall
A1 Paolo Marinho de Andrade Zanotto
YR 2016
UL http://biorxiv.org/content/early/2016/05/10/052340.abstract
AB We present a case of microcephaly associated with Zika virus (ZIKV) in a chronological, multimodal imaging approach, illustrating the hallmarks of this disease on intrauterine morphological ultrasound, transfontanelar ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). We also determined the serological e immunological status of the mother and newborn. Noticeably, there was evidence for maternal infection by ZIKV, cytomegalovirus (CMV), herpes simplex virus (HSV), dengue virus (DENV) and Toxoplasma gondii, which indicates a possible role of previous exposures to STORCH agents and possibly comorbidities in the severe fetal congenital manifestation.Author Summary Zika virus (ZIKV) is an emerging mosquito-borne arbovirus causing dengue-like symptoms. In humans the illness is characterized by malaise and cutaneous rash and absent or short-termed fever. Recently, the Brazilian Ministry of Health reported an outbreak of microcephaly in Brazil as a delayed effect of the 2014-2015 outbreak of ZIKV in the Northeast of Brazil. A 20-fold increase in the notifications of newborns with microcephaly was documented during the second semester of 2015. This increase was almost immediately found to be associated with ZIKV infections, both in Brazil and, retrospectively, in French Polynesia. Herein we report a case of microcephaly associated with ZIKV and we also present evidence of other maternal infections. Our results indicated that, both mother and microcephaly infant had immunologic status compatible with previous exposure (in the mother) by STORCH agents. These indicate a possible role of previous exposures and possibly comorbidities in the severe fetal congenital manifestation. □