TY - JOUR T1 - Conceptual Confusion: The case of Epigenetics JF - bioRxiv DO - 10.1101/053009 SP - 053009 AU - Angela Oliveira Pisco AU - Aymeric Fouquier d’Hérouël AU - Sui Huang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/05/12/053009.abstract N2 - The observations of phenotypic plasticity have stimulated the revival of ‘epigenetics’. Over the past 70 years the term has come in many colors and flavors, depending on the biological discipline and time period. The meanings span from Waddington’s “epigenotype” and “epigenetic landscape” to the molecular biologists’ “epigenetic marks” embodied by DNA methylation and histone modifications. Here we seek to quell the ambiguity of the name. First we place “epigenetics” in the various historical contexts. Then, by presenting the formal concepts of dynamical systems theory we show that the “epigenetic landscape” is more than a metaphor: it has specific mathematical foundations. The latter explains how gene regulatory networks produce multiple attractor states, the self-stabilizing patterns of gene activation across the genome that account for “epigenetic memory”. This network dynamics approach replaces the reductionist correspondence of molecular epigenetic modifications with concept of the epigenetic landscape, by providing a concrete and crisp correspondence. ER -