TY - JOUR T1 - Massively parallel whole-organism lineage tracing using CRISPR/Cas9 induced genetic scars JF - bioRxiv DO - 10.1101/056499 SP - 056499 AU - Jan Philipp Junker AU - Bastiaan Spanjaard AU - Josi Peterson-Maduro AU - Anna Alemany AU - Bo Hu AU - Maria Florescu AU - Alexander van Oudenaarden Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/01/056499.abstract N2 - A key goal of developmental biology is to understand how a single cell transforms into a full-grown organism consisting of many cells. Although impressive progress has been made in lineage tracing using imaging approaches, analysis of vertebrate lineage trees has mostly been limited to relatively small subsets of cells. Here we present scartrace, a strategy for massively parallel whole-organism lineage tracing based on Cas9 induced genetic scars in the zebrafish. ER -