RT Journal Article
SR Electronic
T1 Vision and locomotion shape the interactions between neuron types in mouse visual cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 058396
DO 10.1101/058396
A1 Mario Dipoppa
A1 Adam Ranson
A1 Michael Krumin
A1 Marius Pachitariu
A1 Matteo Carandini
A1 Kenneth D Harris
YR 2016
UL http://biorxiv.org/content/early/2016/06/11/058396.abstract
AB Locomotion profoundly changes sensory responses in mouse primary visual cortex. These changes are thought to arise from a disinhibitory circuit, whereby interneurons expressing vasoactive intestinal peptide (Vip) inhibit those expressing somatostatin (Sst), thus disinhibiting pyramidal cells (Pyr). We studied the effect of locomotion on these cell types and on interneurons expressing parvalbumin (Pvalb) in layer 2/3 of mouse V1, and found inconsistencies with the disinhibitory model. Locomotion increased Sst cell responses to large stimuli and to full field gray screen, without decreasing them in Vip cells. Moreover, it increased Vip cell responses to small stimuli, without decreasing them in Sst cells. Signal and noise correlations between cell types provided further evidence against the disinhibitory model. Our data resolve apparent contradictions in the literature and suggest an alternative to the disinhibitory model, where Vip and Sst cells inhibit each other in a circuit whose effect depends on stimulus and behavioral state.