PT  - JOURNAL ARTICLE
AU  - Y-h. Taguchi
TI  - microRNA-mRNA interaction identification in Wilms tumor using principal component analysis based unsupervised feature extraction
AID  - 10.1101/059295
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 059295
4099  - http://biorxiv.org/content/early/2016/06/16/059295.short
4100  - http://biorxiv.org/content/early/2016/06/16/059295.full
AB  - Wilms tumor is one of lethal child renal cancers, for which no known disease causing mechanisms exist. In this paper, we tried to identify possible disease causing microRNA(miRNA)-mRNA pairs (interactions) by analyzing (partially matched) miRNA/mRNA gene expression profiles with the recently proposed principal component analysis based unsupervised feature extraction. It successfully identified multiple miRNA-mRNA pairs whose biological natures are convincing. Correlation coefficients between miRNA and mRNA expression in matched parts of profiles turned out to be significantly negative. Constructed miRNA-mRNA network will be a key to understand Wilms tumor causing mechanisms.