TY - JOUR T1 - Accounting for genetic interactions is necessary for accurate prediction of extreme phenotypic values of quantitative traits in yeast JF - bioRxiv DO - 10.1101/059485 SP - 059485 AU - Simon K. G. Forsberg AU - Joshua S. Bloom AU - Sadhu Meru J. AU - Kruglyak Leonid AU - Örjan Carlborg Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/17/059485.abstract N2 - Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, that most genetic variance in populations is additive. Here we describe networks of capacitating genetic interactions that contribute to quantitative trait variation in a large yeast intercross population. The additive variance explained by individual loci in a network is highly dependent on the allele frequencies of the interacting loci. Accurate predictions of phenotypes for some multi-locus genotype classes in an epistatic network often require accounting for the interactions. We discuss the implications of these results for attempts to dissect genetic architectures and to predict individual phenotypes and long-term responses to selection. ER -