PT - JOURNAL ARTICLE AU - Sarah A Gagliano AU - Jennie G Pouget AU - John Hardy AU - Michael R Barnes AU - Jo Knight AU - Mina Ryten AU - Michael E Weale TI - Genetic variability in both the adaptive and innate immune systems contribute to Alzheimer’s and Parkinson’s disease risk AID - 10.1101/059519 DP - 2016 Jan 01 TA - bioRxiv PG - 059519 4099 - http://biorxiv.org/content/early/2016/06/17/059519.short 4100 - http://biorxiv.org/content/early/2016/06/17/059519.full AB - Neurodegenerative disorders are devastating diseases with a worldwide health-care burden. Studies have demonstrated enrichment of disease-associated genetic variants with functional genomic annotations. Determining associated cell-types is important to understand pathogenicity.We obtained GWAS summary statistics from Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and frontotemporal dementia (FTD). We applied stratified LD score regression to determine if functional categories are enriched for heritability.There was little enrichment of brain annotations, but annotations from both the innate and adaptive immune systems were enriched for MS (as expected), AD, and PD, in decreasing order of statistical significance.