TY - JOUR T1 - CAMSA: a Tool for Comparative Analysis and Merging of Scaffold Assemblies JF - bioRxiv DO - 10.1101/069153 SP - 069153 AU - S. S. Aganezov AU - M. A. Alekseyev Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/08/11/069153.abstract N2 - Motivation Despite the recent progress in genome sequencing and assembly, many of the currently available assembled genomes come in a draft form. Such draft genomes consist of a large number of genomic fragments (scaffolds), whose positions and orientations along the genome are unknown. While there exists a number of methods for reconstruction of the genome from its scaffolds, utilizing various computational and wet-lab techniques, they often can produce only partial error-prone scaffold assemblies. It therefore becomes important to compare and merge scaffold assemblies produced by different methods, thus combining their advantages and highlighting present conflicts for further investigation. These tasks may be labor intensive if performed manually.Results We present CAMSA—a tool for comparative analysis and merging of two or more given scaffold assemblies. The tool (i) creates an extensive report with several comparative quality metrics; (ii) constructs a most consistent combined scaffold assembly; and (iii) provides an interactive framework for a visual comparative analysis of the given assemblies.Availability CAMSA is available for download from http://cblab.org/camsa/. ER -