RT Journal Article
SR Electronic
T1 Zika virus replication in the mosquito <em>Culex quinquefasciatus</em> in Brazil
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 073197
DO 10.1101/073197
A1 D. R. D. Guedes
A1 M. H. S. Paiva
A1 M. M. A. Donato
A1 P. P. Barbosa
A1 L. Krokovsky
A1 S. W. dos S. Rocha
A1 K. L. A. Saraiva
A1 M. M. Crespo
A1 R. M. R. Barbosa
A1 C. M. F. Oliveira
A1 M. A. V. Melo-Santos
A1 L. Pena
A1 M. T. Cordeiro
A1 R. F. de O. França
A1 A. L. S, de Oliveira
A1 W. S. Leal
A1 C. A. Peixoto
A1 C. F. J. Ayres
YR 2016
UL http://biorxiv.org/content/early/2016/09/02/073197.abstract
AB Zika virus (ZIKV) is a flavivirus that has recently been associated with increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide, but there is evidence of other mosquito species, including Culex quinquefasciatus, playing a role in the Brazilian outbreak. To test this hypothesis, we experimentally compared the vectorial competence of laboratory-reared A. aegypti and C. quinquefasciatus. We found ZIKV in the midgut, salivary glands, and saliva of artificially fed C. quinquefasciatus. Additionally, we collected ZIKV-infected C. quinquefasciatus from urban areas of high microcephaly incidence in Recife, Brazil. Take into account; these findings indicate that there may be a wider range of vectors for ZIKV than anticipated.