PT - JOURNAL ARTICLE AU - Michael L. Waskom AU - Anthony D. Wagner TI - Distributed representation of context by intrinsic subnetworks in prefrontal cortex AID - 10.1101/074880 DP - 2016 Jan 01 TA - bioRxiv PG - 074880 4099 - http://biorxiv.org/content/early/2016/09/13/074880.short 4100 - http://biorxiv.org/content/early/2016/09/13/074880.full AB - Human prefrontal cortex supports flexible decision-making by representing abstract information about task context. The organizational basis of these context representations, and of representations underlying other higher-order processes, is unknown. Here, we use multivariate decoding and analyses of spontaneous correlations to show that context representations are distributed across subnetworks within prefrontal cortex. Examining targeted prefrontal regions, we found that pairs of voxels with similar context preferences exhibited spontaneous correlations that were approximately twice as large as those between pairs with opposite context preferences. This subnetwork organization was stable across task-engaged and resting states, suggesting that abstract context representations are constrained by an intrinsic functional architecture. These results reveal a principle of fine-scaled functional organization in association cortex.