TY - JOUR T1 - Comparative analysis of dengue and Zika outbreaks reveals differences by setting and virus JF - bioRxiv DO - 10.1101/043265 SP - 043265 AU - Sebastian Funk AU - Adam J. Kucharski AU - Anton Camacho AU - Rosalind M. Eggo AU - Laith Yakob AU - Lawrence M. Murray AU - W. John Edmunds Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/06/043265.abstract N2 - The pacific islands of Micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. In outbreaks on small islands, the susceptible population is usually well defined, and there is no co-circulation of pathogens. Because of this, analysing such outbreaks can be useful for understanding the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as Zika virus. Here, we compared three outbreaks of dengue and Zika virus in two different island settings in Micronesia, the Yap Main Islands and Fais, using a mathematical model of transmission dynamics, making full use of commonalities in disease and setting between the outbreaks. We found that the estimated reproduction numbers for Zika and dengue were similar when considered in the same setting, but that, conversely, reproduction number for the same disease can vary considerably by setting. On the Yap Main Islands, we estimated a reproduction number of 8.0–16 (95% Credible Interval (CI)) for the dengue outbreak and 4.8–14 (95% CI) for the Zika outbreak, whereas for the dengue outbreak on Fais our estimate was 28–102 (95% CI). We further found that the proportion of cases of Zika reported was smaller (95% CI 1.4%–1.9%) than that of dengue (95% CI 47%–61%). We confirmed these results in extensive sensitivity analysis. They suggest that models for dengue transmission can be useful for estimating the predicted dynamics of Zika transmission, but care must be taken when extrapolating findings from one setting to another.Author Summary Dengue and Zika are related viruses and are both transmitted by mosquitoes. Dengue is well described and affects people around the world. Zika, on the other hand has only recently caused outbreak in human populations, and it has been suggested that its behaviour might similar dengue. To investigate this, we compared three outbreaks of dengue and Zika in island populations of the pacific: two dengue outbreaks and one Zika outbreak. Island outbreaks are useful laboratories for understanding the spread of infections because they are usually short, well-identified episodes, whereas elsewhere it can be difficult to identify the properties of outbreaks when different viruses spread at the same time. In our investigation of the outbreaks in Micronesia we found that dengue and Zika virus did, indeed, behave similar in outbreaks they caused on the Yap Main Islands. A dengue outbreak on the smaller island of Fais, on the other hand, was different from the dengue outbreak on Yap in that transmission seems to have been more efficient. We conclude that dengue outbreaks are indeed a good model for Zika outbreaks when considered in the same setting, but that one must be careful when comparing outbreaks in different settings. ER -