RT Journal Article
SR Electronic
T1 Measurements of morphological and biochemical alterations in individual neuron cells associated with early neurotoxic effects in Parkinson’s disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 080937
DO 10.1101/080937
A1 Su-A Yang
A1 Jonghee Yoon
A1 Kyoohyun Kim
A1 YongKeun Park
YR 2016
UL http://biorxiv.org/content/early/2016/10/17/080937.abstract
AB Parkinson’s disease (PD) is a common neurodegenerative disease. However, therapeutic methods of PD are still limited due to complex pathophysiology in PD. Here, we present optical measurements of individual neurons from in vitro PD model using optical diffraction tomography (ODT). By measuring 3-D refractive index distribution of neurons, morphological and biochemical alterations in in-vitro PD model are quantitatively investigated. We found that neurons show apoptotic features in early PD progression. The present approach will open up new opportunities for quantitative investigation of the pathophysiology of various neurodegenerative diseases.