TY - JOUR T1 - Measurements of morphological and biochemical alterations in individual neuron cells associated with early neurotoxic effects in Parkinson’s disease JF - bioRxiv DO - 10.1101/080937 SP - 080937 AU - Su-A Yang AU - Jonghee Yoon AU - Kyoohyun Kim AU - YongKeun Park Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/17/080937.abstract N2 - Parkinson’s disease (PD) is a common neurodegenerative disease. However, therapeutic methods of PD are still limited due to complex pathophysiology in PD. Here, we present optical measurements of individual neurons from in vitro PD model using optical diffraction tomography (ODT). By measuring 3-D refractive index distribution of neurons, morphological and biochemical alterations in in-vitro PD model are quantitatively investigated. We found that neurons show apoptotic features in early PD progression. The present approach will open up new opportunities for quantitative investigation of the pathophysiology of various neurodegenerative diseases. ER -