RT Journal Article
SR Electronic
T1 Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 081968
DO 10.1101/081968
A1 Matthew C. W. Oswald
A1 Paul S. Brooks
A1 Maarten F. Zwart
A1 Amrita Mukherjee
A1 Ryan J. H. West
A1 Khomgrit Morarach
A1 Sean T. Sweeney
A1 Matthias Landgraf
YR 2016
UL http://biorxiv.org/content/early/2016/10/19/081968.abstract
AB Neurons adjust their excitability, connectivity and structure in response to changes in activity, yet how neurons sense their activity level remains unclear. We have found that motorneurons cell-autonomously monitor their activity by responding to the levels of reactive oxygen species (ROS), a metabolic mitochondrial byproduct. The highly conserved Parkinson's disease-linked protein DJ1b is central to this, acting as a redox sensor to regulate pre- and postsynaptic structural plasticity via activation of the PI3Kinase pathway.