RT Journal Article SR Electronic T1 Uncovering the underlying mechanisms and whole-brain dynamics of therapeutic deep brain stimulation for Parkinson’s disease JF bioRxiv FD Cold Spring Harbor Laboratory SP 083162 DO 10.1101/083162 A1 Victor M. Saenger A1 Joshua Kahan A1 Tom Foltynie A1 Karl Friston A1 Tipu Z. Aziz A1 Alexander L. Green A1 Tim J. van Hartevelt A1 Angus B. A. Stevner A1 Henrique M. Fernandes A1 Laura Mancini A1 John Thornton A1 Tarek Yousry A1 Patricia Limousin A1 Ludvic Zrinzo A1 Marwan Hariz A1 Morten L. Kringelbach A1 Gustavo Deco YR 2016 UL http://biorxiv.org/content/early/2016/10/25/083162.abstract AB Deep brain stimulation (DBS) for Parkinson’s disease is a highly effective treatment in controlling otherwise debilitating symptoms yet the underlying brain mechanisms are currently not well understood. We used whole-brain computational modeling to disclose the effects of DBS ON and OFF during collection of resting state fMRI in ten Parkinson’s Disease patients. Specifically, we explored the local and global impact of DBS in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts the global brain dynamics of patients nearer to that of healthy people by significantly changing the bifurcation parameters in brain regions implicated in Parkinson’s Disease. We also found higher communicability and coherence brain measures during DBS ON compared to DBS OFF. Finally, by modeling stimulation we identified possible novel DBS targets. These results offer important insights into the underlying effects of DBS, which may in time offer a route to more efficacious treatments.