RT Journal Article
SR Electronic
T1 CancerGD: a resource for identifying and interpreting genetic dependencies in cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 081992
DO 10.1101/081992
A1 Stephen Bridgett
A1 James Campbell
A1 Christopher J. Lord
A1 Colm J. Ryan
YR 2016
UL http://biorxiv.org/content/early/2016/10/26/081992.abstract
AB Genes whose function is selectively essential in the presence of cancer associated genetic aberrations represent promising targets for the development of precision therapeutics. Here we present CancerGD (www.cancergd.org), a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks.