RT Journal Article
SR Electronic
T1 Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 052282
DO 10.1101/052282
A1 Bartosz Teleńczuk
A1 Nima Dehghani
A1 Michel Le Van Quyen
A1 Sydney S. Cash
A1 Eric Halgren
A1 Nicholas G. Hatsopoulos
A1 Alain Destexhe
YR 2016
UL http://biorxiv.org/content/early/2016/11/02/052282.abstract
AB The local field potential (LFP) is generated by large populations of neurons, but unitary contribution of spiking neurons to LFP is not well characterised. We investigated this contribution in multi-electrode array recordings from human and monkey neocortex by examining the spike-triggered LFP average (st-LFP). The resulting st-LFPs were dominated by broad spatio-temporal components due to ongoing activity, synaptic inputs and recurrent connectivity. To reduce the spatial reach of the st-LFP and observe the local field related to a single spike we applied a spatial filter, whose weights were adapted to the covariance of ongoing LFP. The filtered st-LFPs were limited to the perimeter of 800 μm around the neuron, and propagated at axonal speed, which is consistent with their unitary nature. In addition, we discriminated between putative inhibitory and excitatory neurons and found that the inhibitory st-LFP peaked at shorter latencies, consistently with previous findings in hippocampal slices. Thus, in human and monkey neocortex, the LFP reflects primarily inhibitory neuron activity.