RT Journal Article
SR Electronic
T1 NLR signaling network mediates immunity to diverse plant pathogens
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 090449
DO 10.1101/090449
A1 Chih-Hang Wu
A1 Ahmed Abd-El-Haliem
A1 Tolga O. Bozkurt
A1 Khaoula Belhaj
A1 Ryohei Terauchi
A1 Jack H. Vossen
A1 Sophien Kamoun
YR 2016
UL http://biorxiv.org/content/early/2016/11/29/090449.abstract
AB Plant and animal nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins often function in pairs to mediate innate immunity to pathogens. However, the degree to which NLR proteins form signaling networks beyond genetically linked pairs is poorly understood. In this study, we discovered that a large NLR immune signaling network with a complex genetic architecture confers immunity to oomycetes, bacteria, viruses, nematodes, and insects. The network emerged over 100 million years ago from a linked NLR pair that diversified into up to one half of the NLR of asterid plants. We propose that this NLR network increases robustness of immune signaling to counteract rapidly evolving plant pathogens.