RT Journal Article
SR Electronic
T1 High levels of antibiotic tolerance and persistence are induced by the commercial anti-microbial triclosan
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 090829
DO 10.1101/090829
A1 Corey S. Westfall
A1 Petra Anne Levin
YR 2016
UL http://biorxiv.org/content/early/2016/12/01/090829.abstract
AB Antimicrobial tolerance and bacterial persistence are confounding factors in the treatment of recurrent and chronic infections. Here we report that the anti-microbial additive triclosan renders Escherichia coli and methicillin-resistant Staphylococcus aureus tolerant to a panel of bactericidal antibiotics. Triclosan treatment increased antimicrobial tolerance up to 10,000 fold, amplified persister populations by several orders of magnitude, and in one instance, rendered E. coli refractile to the cell wall active antibiotic, ampicillin.