TY - JOUR T1 - Spatial specificity of the functional MRI blood oxygenation response relative to neuronal activity JF - bioRxiv DO - 10.1101/097287 SP - 097287 AU - Denis Chaimow AU - Essa Yacoub AU - Kâmil Uğurbil AU - Amir Shmuel Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/12/29/097287.abstract N2 - Previous attempts at characterizing the spatial specificity of the blood oxygenation level dependent functional MRI (BOLD fMRI) response by estimating its point-spread function (PSF) have conventionally relied on spatial representations of visual stimuli in area V1. Consequently, their estimates were confounded by the width and scatter of receptive fields of V1 neurons. Here, we circumvent these limits by instead using the inherent cortical spatial organization of ocular dominance columns (ODCs) to determine the PSF for both Gradient Echo (GE) and Spin Echo (SE) BOLD imaging at 7 Tesla. By applying Markov Chain Monte Carlo sampling on a probabilistic generative model of imaging ODCs, we quantified the PSFs that best predict the spatial structure and magnitude of differential ODCs’ responses. Prior distributions for the ODC model parameters were determined by analyzing published data of cytochrome oxidase patterns from post-mortem histology of human V1 and of neurophysio-logical ocular dominance indices. The most probable PSF full-widths at halfmaximum were 0.82 mm (SE) and 1.02 mm (GE). Our results provide a quantitative basis for the spatial specificity of BOLD fMRI at ultra-high fields, which can be used for planning and interpretation of high-resolution differential fMRI of fine-scale cortical organizations. ER -