PT  - JOURNAL ARTICLE
AU  - Benjamin Linard
AU  - Ngoc Hoan Nguyen
AU  - Odile Lecompte
AU  - Olivier Poch
AU  - Julie D. Thompson
TI  - EvoKEN: evolutionary knowledge extraction in networks
AID  - 10.1101/098285
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 098285
4099  - http://biorxiv.org/content/early/2017/01/06/098285.short
4100  - http://biorxiv.org/content/early/2017/01/06/098285.full
AB  - We introduce a multi-factorial, multi-level approach to build and explore evolutionary scenarios of complex protein networks. EvoKEN combines a unique formalism for integrating multiple types of data associated with network molecular components and knowledge extraction techniques for detecting cohesive/anomalous evolutionary processes. We analyzed known human pathway maps and identified perturbations or specializations at the local topology level that reveal important evolutionary and functional aspects of these cellular systems.