RT Journal Article
SR Electronic
T1 Histone 4 acetylation regulates behavioral individuality in zebrafish
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 100230
DO 10.1101/100230
A1 Angel Carlos Román
A1 Julián Vicente-Page
A1 Alfonso Pérez-Escudero
A1 Jose M. Carvajal-González
A1 Pedro M. Fernández-Salguero
A1 Gonzalo G. de Polavieja
YR 2017
UL http://biorxiv.org/content/early/2017/01/13/100230.abstract
AB Behavioral individuality arises even in isogenic populations under identical environments, but its underlying mechanisms remain elusive. We found that inbred and isogenic zebrafish (Danio rerio) larvae showed consistent behavioral individuality when swimming freely in identical wells or in reaction to stimuli. We also found that behavioral individuality depends on the histone acetylation levels. Individuals with high levels of histone 4 acetylation behaved similar to the average of the population, but those with low levels deviated and showed behavioral individuality. More precisely, we found behavioral individuality to be related to individuality in histone 4 acetylation of a set of genomic regions related to neurodevelopment. We found evidence that this modulation depends on a complex of Yin Yang 1 (YY1) and histone deacetylase 1 (HDAC1). We suggest, using stochastic modelling, that this complex is part of the molecular machinery giving individuality in histone acetylation in neurodevelopmental genes ultimately responsible for behavioral individuality.