PT - JOURNAL ARTICLE AU - Insuk Lee AU - Eiru Kim AU - Edward M. Marcotte TI - Modes of interaction between individuals dominate the topologies of real world networks AID - 10.1101/011288 DP - 2014 Jan 01 TA - bioRxiv PG - 011288 4099 - http://biorxiv.org/content/early/2014/11/10/011288.short 4100 - http://biorxiv.org/content/early/2014/11/10/011288.full AB - We find that the topologies of real world networks, such as those formed within human societies, by the Internet, or among cellular proteins, are dominated by the mode of the interactions considered among the individuals. Consequently, a major dichotomy in previously studied networks arises from modeling networks in terms of pairwise versus group tasks. The former often intrinsically give rise to scale-free, disassortative, hierarchical networks, whereas the latter often give rise to broad-scale, assortative, nonhierarchical networks. These dependencies explain contrasting observations among previous topological analyses of real world complex systems. We also observe this trend in systems with natural hierarchies, in which alternate representations of the same networks, but which capture different levels of the hierarchy, manifest these signature topological differences. For example, in both the Internet and cellular proteomes, networks of lower-level system components (routers within domains or proteins within biological processes) are assortative and nonhierarchical, whereas networks of upper-level system components (internet domains or biological processes) are disassortative and hierarchical. Our results demonstrate that network topologies of complex systems must be interpreted in light of their hierarchical natures and interaction types.