RT Journal Article
SR Electronic
T1 The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 104299
DO 10.1101/104299
A1 Kay-Dietrich Wagner
A1 Yilin Ying
A1 Waiian Leong
A1 Jie Jiang
A1 Xuefei Hu
A1 Yi Chen
A1 Jean-François Michiels
A1 Yiming Lu
A1 Eric Gilson
A1 Nicole Wagner
A1 Jing Ye
YR 2017
UL http://biorxiv.org/content/early/2017/01/30/104299.abstract
AB Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends, some evidence suggests that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development throughout the lifespan.