TY - JOUR T1 - Cancer Cell Line Profiler (CCLP): a webserver for the prediction of compound activity across the NCI60 panel JF - bioRxiv DO - 10.1101/105478 SP - 105478 AU - Isidro Cortés-Ciriano AU - Daniel S. Murrell AU - Bernard Chetrit AU - Andreas Bender AU - Thérèse Malliavin AU - Pedro J. Ballester Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/02/02/105478.abstract N2 - Summary CCLP (Cancer Cell Line Profiler) is a webserver for the prediction of compound activity across the NCI60 panel. CCLP uses a multi-task Random Forest model trained on 941,831 data-points that integrates structural information from 17,142 compounds and multi-omics data sets from 59 cancer cell lines. In addition, CCLP also implements conformal prediction to provide individual prediction errors at several confidence levels. CCLP computes compound descriptors for a set of input molecules and predicts their activity across the NCI60 panel. The output of running CCLP consists of one barplot per input compound displaying the predicted activities and errors across the NCI60 panel, as well as a text file reporting the predicted activities and errors in predictionAvailability CCLP is freely available on the web at cclp.marseille.inserm.fr ER -