TY - JOUR T1 - A rare <em>IL2RA</em> haplotype identifies SNP rs61839660 as causal for autoimmunity JF - bioRxiv DO - 10.1101/108126 SP - 108126 AU - Daniel B. Rainbow AU - Marcin Pekalski AU - Antony J. Cutler AU - Oliver Burren AU - Neil Walker AU - John A. Todd AU - Chris Wallace AU - Linda S. Wicker Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/02/14/108126.abstract N2 - IL2RA is associated with multiple autoimmune diseases including type 1 diabetes (T1D). Higher expression of IL2RA mRNA and its protein product CD25 in T lymphocytes is associated with a T1D-protective haplotype. Here we show that a rare variation of this haplotype that loses the protective allele at a single SNP, rs61839660, reduces IL2RA expression and T1D protection, identifying it as the causal factor in disease. ER -