TY - JOUR T1 - Genomic architecture of human neuroanatomical diversity JF - bioRxiv DO - 10.1101/001198 SP - 001198 AU - Roberto Toro AU - Jean-Baptiste Poline AU - Guillaume Huguet AU - Eva Loth AU - Vincent Frouin AU - Tobias Banaschewski AU - Gareth J Barker AU - Arun Bokde AU - Christian Büchel AU - Fabiana M Carvalho AU - Patricia Conrod AU - Mira Fauth-Bühler AU - Herta Flor AU - Jürgen Gallinat AU - Hugh Garavan AU - Penny Gowland AU - Andreas Heinz AU - Bernd Ittermann AU - Claire Lawrence AU - Hervé Lemaître AU - Karl Mann AU - Frauke Nees AU - Tomáš Paus AU - Zdenka Pausova AU - Marcella Rietschel AU - Trevor Robbins AU - Michael N Smolka AU - Andreas Ströhle AU - Gunter Schumann AU - Thomas Bourgeron AU - and the IMAGEN consortium ( ) Y1 - 2013/01/01 UR - http://biorxiv.org/content/early/2013/12/05/001198.abstract N2 - Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here we show, based on our analyses of neuroimaging and whole-genome genotyping data from 1,765 subjects, that up to 54% of this heritability is captured by large numbers of single nucleotide polymorphisms of small effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease. ER -