PT  - JOURNAL ARTICLE
AU  - Michael Plaksin
AU  - Eitan Kimmel
AU  - Shy Shoham
TI  - Thermal transients excite neurons through universal intramembrane mechano-electrical effects
AID  - 10.1101/111724
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 111724
4099  - http://biorxiv.org/content/early/2017/02/25/111724.short
4100  - http://biorxiv.org/content/early/2017/02/25/111724.full
AB  - Modern advances in neurotechnology rely on effectively harnessing physical tools and insights towards remote neural control, thereby creating major new scientific and therapeutic opportunities. Specifically, rapid temperature pulses were shown to increase membrane capacitance, causing capacitive currents that explain neural excitation, but the underlying biophysics is not well understood. Here, we show that an intramembrane thermal-mechanical effect wherein the phospholipid bilayer undergoes axial narrowing and lateral expansion accurately predicts a potentially universal thermal capacitance increase rate of ~0.3%/°C. This capacitance increase and concurrent changes in the surface charge related fields lead to predictable exciting ionic displacement currents. The new theory’s predictions provide an excellent agreement with multiple experimental results and indirect estimates of latent biophysical quantities. Our results further highlight the role of electro-mechanics in neural excitation; they may also help illuminate sub-threshold and novel physical cellular effects, and could potentially lead to advanced new methods for neural control.