TY - JOUR T1 - Multivariate Genome-Wide and Integrated Transcriptome and Epigenome-Wide Analyses of the Well-being Spectrum JF - bioRxiv DO - 10.1101/115915 SP - 115915 AU - B.M.L. Baselmans AU - J. Jansen AU - J. van Dongen AU - Y. Bao AU - M. Smart AU - M. Kumari AU - A. Abdellaoui AU - M. P. van de Weijer AU - G. Willemsen AU - J.J. Hottenga AU - BIOS consortium AU - Social Science Genetic Association Consortium AU - E.J.C. de Geus AU - D.I. Boomsma AU - M.G. Nivard AU - M. Bartels Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/03/11/115915.abstract N2 - Several phenotypes related to well-being (e.g., life satisfaction, positive affect, neuroticism, and depressive symptoms), are genetically highly correlated (| rg | > .75). Multivariate analyses of these traits, collectively referred to as the well-being spectrum, reveals 24 genome-wide significant loci. We integrated the genetic findings with large human transcriptome and epigenome datasets. Integrated analyses implicate gene expression at 48 additional loci and CpG methylation at 28 additional loci in the etiology of well-being. ER -