TY - JOUR T1 - Inferring Within-Host Bottleneck Size: A Bayesian Approach JF - bioRxiv DO - 10.1101/116194 SP - 116194 AU - R. Dybowski AU - O. Restif AU - D.J. Price AU - P. Mastroeni Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/03/13/116194.abstract N2 - A number of approaches exist for bottleneck-size estimation with respect to within-host bacterial infections; however, some are more appropriate than others under certain circumstances. A Bayesian comparison of several approaches is made in terms of the availability of isogenic multitype bacteria (e.g., WITS), knowledge of post-bottleneck dynamics, and the suitability of dilution with monotype bacteria. The results are summarised by a guiding flowchart.A sampling approach to bottleneck-size estimation is also introduced. ER -